A common property of signalling receptor endocytosis is the efficient sorting ... by ligands that dissociate from them in endosomes. The EGFR agonist TGFα, for example, is released from the ...
Specifically, lower activation of the epidermal growth factor receptor (EGFR) signaling pathway occurs following reduced endocytosis. Decreased EGFR pathway activity allows LECs to switch from ...
These targets included (1) Insulin-like Growth Factor 2 Receptor (IGF2R), which is found in most tissues and triggers endocytosis through receptor dimerization ... As a proof of concept, they targeted ...
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