A common property of signalling receptor endocytosis is the efficient sorting ... by ligands that dissociate from them in endosomes. The EGFR agonist TGFα, for example, is released from the ...

These targets included (1) Insulin-like Growth Factor 2 Receptor (IGF2R), which is found in most tissues and triggers endocytosis through receptor dimerization, (2) Asialoglycoprotein Receptor ... As ...

Results: The expression of EGFR, a member of the receptor tyrosine kinase (RTK) family, was significantly increased in acquired regorafenib-resistant HCC cells compared with parental cells.

EGF receptor (EGFR) and HER2 are two members of the ErbB/HER-family of tyrosine-kinase receptors that are frequently altered in breast cancer and several other malignancies, which inspired the ...

A new BLA for Dato-DXd targets EGFR-mutated NSCLC, following withdrawal of a previous application based on TROPION-Lung01 trial data. The new submission is supported by phase 2 TROPION-Lung05 trial ...

Ligand binding triggers endocytosis and subsequent cleavages (S2 and S3), releasing the Notch intracellular ... Rova-T consists of a humanized anti-DLL3 monoclonal antibody (SC16) linked to a PBD ...

The success of agents that inhibit tumor necrosis factor (TNF), such as infliximab, adalimumab and etanercept, has led to a desire for orally available small molecules that have a better safety ...