Notch signaling and epithelial-to-mesenchymal transition (EMT). Transformed, recruited and differentially activated cells surrounding the tumor form the tumor microenvironment. These cells inhibit ...

Tumor cells undergoing epithelial–mesenchymal transition (EMT) can profoundly modulate their microenvironment via enhanced secretion of multiple soluble factors, including IL-8, IL-6 ...

How synthetic bacteria can break down the extracellular matrices of solid tumors to make them more susceptible to cancer ...

the impact of obesity/chronic inflammation on tumor immune microenvironment, and white blood cell immune environment. Future ...

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Cancer development and ...

Hepatocellular carcinoma (HCC) is a significant global health issue, ranking as the sixth most prevalent malignancy and the ...

Studies to determine whether epigenetic reprogramming of EMT and/or the tumor microenvironment will improve response to standard-of-care chemotherapy and immunotherapy. View a listing of lab members ...

Study uses spatial transcriptomics to map intratumoral heterogeneity and microenvironmental dynamics in triple-negative ...

Researchers investigating ways to reduce exhaustion in cancer-fighting T-cells found that the Golgi apparatus can be used as ...

Furthermore, researchers have observed that the two cell populations have very different locations within the tumor. The ...

The tumor cells are too varied, and the microenvironment is too tumor-friendly. Researchers have now developed an immunotherapy that not only attacks the tumor -- it also turns its ...