Study uses spatial transcriptomics to map intratumoral heterogeneity and microenvironmental dynamics in triple-negative ...

On the other hand, the tumor microenvironment (TME) comprising of tumor cells ... Alternatively, the transcription factor Zinc-finger E-box-binding homeobox 1 (ZEB1) facilitates EMT and is crucial for ...

The model opens up new possibilities for studying fibroblast-driven effects in diverse settings, which is crucial for understanding potential tumor microenvironment manipulations that could enhance ...

The study, which was published in the Journal of Clinical Investigation on Friday, found that COVID infection was linked to cancer regression, which could serve as a foundation for new cancer ...

They focused, particularly, on immune cells called myeloid-derived suppressor cells (MDSCs), which accumulate in the tumor microenvironment and inhibit other immune cells from fighting cancer ...

Rather than being a binary switch from an epithelial to a mesenchymal state, cells undergoing EMT can assume a spectrum of intermediate states, some of which may reshape the tumor microenvironment by ...

These EMT states reside within specific physical niches, characterized by unique stromal cell populations. Understanding the cellular interactions within the tumor microenvironment (TME) and their ...

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, People’s Republic of China ...

School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, Henan, P. R. China Pingyuan Laboratory, Xinxiang 453007, Henan, P. R. China ...

The tumor microenvironment (TME) plays a crucial role in cancer development and metastasis. This review summarizes the current research on how the TME promotes metastasis through molecular pathways, ...

Solid tumors create a hostile microenvironment with immunosuppressive factors, such as regulatory T cells and tumor-associated macrophages, leading to CAR T cell exhaustion. Low pH, hypoxia (Low ...