Cancer cells impair monocyte-mediated T-cell activation by disrupting inflammatory pathways in the tumor microenvironment.

A study from the University of Michigan Health Rogel Cancer Center may have—at last—cracked the cold case of immunotherapy ...

Prostate cancer and other cancers characterized by “cold” tumors could become more responsive to checkpoint blockade if UBA1 is inhibited.

Findings indicate a serine/glycine-free diet can reduce colorectal cancer growth and enhance immune response, offering ...

University of Michigan researchers identified UBA1 as a key player in immunotherapy resistance. Inhibiting UBA1 boosts T-cell ...

In a recent article, researchers explored how calcium carbonate nanoparticles enhance T cell activation through calcium ...

Depletion of either CD8+ or CD4+ T cells led to a complete loss of age-associated differences ... These results demonstrate that the aging tumor immune microenvironment significantly impacts tumor ...

Cancer immunotherapy has been revolutionized by targeting specific immune subsets within the tumor microenvironment, where T cells play a pivotal role. Gene-engineered T cell strategies and immune ...