Cancer cells impair monocyte-mediated T-cell activation by disrupting inflammatory pathways in the tumor microenvironment.

A study from the University of Michigan Health Rogel Cancer Center may have—at last—cracked the cold case of immunotherapy ...

Prostate cancer and other cancers characterized by “cold” tumors could become more responsive to checkpoint blockade if UBA1 is inhibited.

Findings indicate a serine/glycine-free diet can reduce colorectal cancer growth and enhance immune response, offering ...

University of Michigan researchers identified UBA1 as a key player in immunotherapy resistance. Inhibiting UBA1 boosts T-cell ...

In a recent article, researchers explored how calcium carbonate nanoparticles enhance T cell activation through calcium ...

The cancer microenvironment, or tumour microenvironment, describes the non-cancerous cells present in the tumour. These include fibroblasts, immune cells and cells that comprise the blood vessels.

Cancer immunotherapy has been revolutionized by targeting specific immune subsets within the tumor microenvironment, where T cells play a pivotal role. Gene-engineered T cell strategies and immune ...

A study from the University of Michigan Health Rogel Cancer Center may have, at last, cracked the cold case of immunotherapy resistance.The research ...

老规矩，奇点糕开头先问大家一个问题：在激活CD8+T细胞抗肿瘤免疫应答时，有哪些细胞会起到重要作用呢？回答树突状细胞（DCs）是肯定没问题的，它们的抗原呈递功能确实广为人知，但各位要记住了，从今天开始DCs可就不是问题唯一的“正解”了。因为在今天的《 ...