Since the application of molecular biology in cancer biology, lung cancer research has classically focused on molecular drivers of disease. One such pathway, the hypoxic response pathway, is ...

The interplay between hypoxic and acidic conditions in the tumor microenvironment is unclear. Here, the authors show that hypoxic and acidic tumor cells do not fully overlap and display a ...

Expression of Negative Regulators of the Hypoxic Response Pathway is Altered in NSCLC Given that HIF1 and HIF2 have such wide ranging transcriptional targets; it is essential that the hypoxic ...

I n the complex landscape of cancer, tumors create their own microenvironment, often marked by low oxygen levels, a condition known as hypoxia. Hypoxia arises as tumors grow rapidly, outpacing ...

The present study aimed to develop an ex vivo model that could mimic the pre-metastatic tumor microenvironment, incorporating factors such as hypoxia, nutrient scarcity, and interactions with ...

Deep in a tumor, full of rapidly dividing cells, cancer cells are faced with a lack of oxygen, a condition called hypoxia. Cancer cells that survive these tough environments end up seeking what ...

In a study published in Cell Reports Physical Science on Nov. 25, a research team reported the development of an innovative ...

Deep in a tumor, full of rapidly dividing cells, cancer cells are faced with a lack of oxygen, a condition called hypoxia. Cancer cells that survive these tough environments end up seeking what ...

Researchers advance CAR T cell therapy for solid tumors by innovating ways to overcome the unique barriers of solid tumor ...

Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...

Natural killer (NK) cells are key innate immune lymphocytes, which play important roles against tumors. However, ...