As an important regression factor in cardiovascular diseases, regulatory CD4+ Foxp3+T cells (Tregs) are a highly oxidative lymphocyte subset, and Tregs heavily rely on fatty acids to fuel their ...

Our objective of this study was to elucidate the molecular and inflammatory mechanisms by which CD39 activity modulates atherosclerosis Approach and Results: Here we identify that the genotype of SNP ...

Furthermore, TAMs can secrete VEGF-α to facilitate stromal angiogenesis, thereby further promoting the progression of HCC (Banerjee ... The interaction between myeloid and stromal cells has received ...

Although the immune suppression function of CXXC1 KO Treg is comparable to WT Treg in an in vitro assay, these KO Tregs failed to suppress autoimmune diseases such as EAE and colitis in Treg transfer ...

There is growing interest in the therapeutic potential of adoptively transferring healthy Tregs into patients with a wide range of conditions, including IBD and autoimmune disease, in an attempt to ...

Coya sees IL-2 as a molecule that can boost the number and power of regulatory T cells (Tregs), leading it to study it as a single agent, COYA 301, and pair the cytokine with the recombinant ...

I believe the opportunities ahead of us in 2025 and beyond are what investors, stockholders, and patients should be most excited about. Our science and approach of regulating Tregs is now validated in ...

These data validate the understanding that Tregs are enhanced only at lower IL-2 levels, whereas higher IL-2 levels reduce Treg function. There is an inverse relationship, if you will, between ...