Novel chemical and biological delivery strategies as well as mechanistic investigations are needed to realize the full therapeutic potential of this promising signaling pathway. This Research Topic ...

1Department of Cancer Biology and Genetics, James Comprehensive Cancer Center, Wexner Medical Center, The Ohio State University, Columbus, Ohio. 3Pelotonia Institute for Immuno-Oncology, James ...

Specific inhibition of this pathway has been shown to alleviate ALI symptoms ... United States), and titrated with diluted GSDMD (Cell Signaling Technology, United States), STING, RIPK3, Caspase-3, ...

January 17, 2025 • The Jan. 30 event will stream live and raise money for those impacted by the wildfires.

One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...

HDAC6 deficiency or inhibition impairs HSV-1 infection via the type l interferon pathway in vitro and in mice. HDAC6 negatively modulates cGAS-STING signaling. HDAC6 interacts with and deacetylates ...

This exciting collection highlights the most recent content on host-pathogen immunity and the signaling events that govern host defense across the EMBO Press journals, covering various aspects of the ...

A severe life-threatening allergic reaction is called anaphylaxis. The main symptoms are hives with trouble breathing and swallowing. It starts within 2 hours of the sting. This severe reaction to bee ...

View full profile. Learn about our editorial policies. When STING is triggered, TANK-binding kinase (TBK1) activates and leads to interferon production. However, Tan and his team wanted to identify ...