Because a protein’s structure helps determine its biological ... drug discovery researchers still need the old-fashioned synthetic organic chemistry expertise that medicinal chemists have ...
The chemistry of amino acid side chains is critical to protein structure because these side chains can bond with one another to hold a length of protein in a certain shape or conformation.
The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...