We purchased antibodies against total p53 and Ser15-phosphorylated p53 from Transductional Signaling Cell, and antibodies against Bclx and Bax and against p21 from PharMingen and Calbiochem ...

School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China ...

Kindlin-2 acts as a physical bridge that links TGFbR1 and Integrins to activate the non-canonical TGF-β oncogenic signaling. In the nucleus, Kindlin-2 associate with p53 to regulate cancer cell ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

A groundbreaking approach slows tumor growth while boosting the immune system’s defense against cancer cells. Prostate cancer ranks as the second most common cancer among men globally. Despite recent ...

Simultaneously, caspase-2 activates the well-known tumor suppressor p53, which initiates additional signaling pathways that also result in cell death. This "double strike" ensures that cells with ...

Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University ...

Through studies of proteins that regulate p53, scientists at St ... ranging from transcription to cell signaling. Generally, condensates do this by temporarily increasing the localized ...