The classic estrogen receptor signaling pathway occurs through the entry of estrogen into the cell, translocation to the nucleus, interaction with the nuclear estrogen receptor (ER) α or β ...

Weill Cornell Medicine researchers have determined the full-length structure of a blood pressure-regulating hormone receptor for the first time, uncovering how it functions, which may enable ...

Estradiol, endogenous T3 and glucocorticoids act through dedicated nuclear steroid hormone receptors to mediate negative feedback on respective pituitary stimulatory signals. CRH, corticotropin ...

That is a fact and it’s a big advancement. And the quality of life for people with metastatic breast cancer has also improved. If you have hormone receptor-positive breast cancer, which means it needs ...

In these cancers, estrogen can bind to receptors on cancer cells, fueling their growth and spread. Treatments for estrogen-dependent cancers often focus on reducing estrogen levels or blocking ...

FOXP3 + regulatory T cells (Treg cells) are key for immune homeostasis. Here, we reveal that nuclear receptor corepressor 1 (NCOR1) controls naïve and effector Treg cell states. Upon NCOR1 deletion in ...

Breast cancers sensitive to hormones are typically referred to as hormone receptor–positive (HR-positive) but may also be called hormone responsive or hormone dependent. How do hormones ...

Bayer's efforts to expand Nubeqa's label in prostate cancer make progress with the FDA's acceptance of the company's sNDA.

OCU410ST leverages an AAV delivery platform for the RORA gene, illustrating Ocugen’s innovative modifier gene therapy ...

Estrogen Receptor Subtypes & Bioidentical Estrogens Estrogen-receptor subtypes may influence how various estrogens act in different tissues. Estradiol binds equally to estrogen receptors α and ß ...

HER2-positive breast cancers have abnormally high levels of HER2 receptors, whereas HER2-negative breast cancers don’t. There are a few differences when looking at HER2-positive vs. HER2-negative ...