Profluent Demonstrates AI Can Engineer Protein-DNA Interactions Without Iterative Laboratory Screening Protein2PAM model enables single-shot customization of Cas enzymes for alternate PAM recognition, ...
A single amino acid change in a neuronal ion channel called KCNQ2 blocks ion flow, prevents protein localization on axons, and results in severe epilepsy and slowed neurological development.
The advent of cost-effective DNA sequencing technologies has spurred significant developments in the identification of genetic variants, considerably ...