Mitochondria in intact cells can transiently accumulate calcium during cell stimulation. The heterogeneity of the response, the extremely high calcium concentrations reached in the mitochondrial ...

Mitochondrial dysfunction in the brain can disrupt the balance of calcium ions inside and outside neurons, making them fire more readily than they should. Kubota-Sakashita had previously found ...

Inhibition of low-level endoplasmic reticulum-to-mitochondria calcium ion transfer is toxic, specifically to cancer cells. An unexpected dependency on this transfer to mitochondria exists for a ...

Tan, A.R., Cai, A.Y., Deheshi, S., Rintoul G.L. Elevated intracellular calcium causes distinct mitochondrial remodelling and calcineurin-dependent fission in ...

Researchers discover how mitochondria not only produce energy but also influence inflammation.

There are multiple sources for these Ca 2+ increases, including IP3 receptor–mediated Ca 2+ release from the endoplasmic reticulum, release from mitochondria, and influx across the plasma through ion ...

The British Heart Foundation’s Reflections of Research competition showcases beautiful images captured by researchers studying heart and circulatory disease ...

This interaction significantly reduced the formation of mitochondria-associated endoplasmic reticulum membranes (MAM) and ...

The nuclei, which contain genetic material, are shown in blue, and calcium is labelled in green. Mitochondria, the ...