In this study, our results uncover the function and mechanism of CHMP5 in the regulation of cell senescence and bone formation in osteogenic cells. Deletion of Chmp5 causes endolysosomal dysfunction ...

This is a catastrophic injury, with extensive damage to the joint surface, fragmentation of the widened flare (metaphysis) of the distal radius, and damage to the shaft of the radius and/or the ...

The past decade has seen significant advances in our understanding of skeletal homeostasis and the mechanisms that mediate the loss of bone integrity in disease. Recent breakthroughs have arisen ...

From the Center for Systems Biology (W.C.P., M.N., F.K.S.), Massachusetts General Hospital and Harvard Medical School, Boston. From the Center for Systems Biology (W ...

Pediatric elbow fractures are extremely common. It has been estimated that they account for approximately 65% of all fractures and dislocations in children. Supracondylar fractures constitute the ...