A standard treatment for mastocytosis is difficult to apply to individual patients based on the variable clinical course. A general consensus for using antimediator agents such as antihistamines ...

The lesions in TMEP are not pruritic and do not produce Darier's sign because mast cell proliferation may not be sufficient to produce significant degranulation (Alto & Clarcq, 1999; Hogan & Lewis ...

umin.ac.jp Objective Extracellular ATP mediates mast cell-dependent intestinal inflammation via P2X7 purinoceptors. We have previously shown that CD300f (also called the leucocyte ...

Keywords: Chronic inducible urticaria; cold urticaria, cholinergic urticaria, contact urticaria, delayed pressure urticaria, immunoglobulin E, mast cells, patient-reported outcomes, provocation ...

In this study, Hoxb8 mast cells (Hoxb8 MCs) were sensitized with sera from 112 peanut-allergic and peanut-tolerant participants. Upon exposure to varying doses of peanut extract, degranulation of ...

Nov. 21, 2024 — Researchers have analyzed the entire mouse intestine, mapping gene expression and cell states and location in the healthy gut and in response to perturbations such as inflammation.

22 Visceral hypersensitivity could in principle result from a number of peripheral (eg, mucosal immune activation, mast cell degranulation, altered flora) as well as from central mechanisms. A large ...

This image provided by Ana-Maria Cujba shows blood vessels in a portion of the human small intestine, March 21, 2024. (Ana-Maria Cujba/Wellcome Sanger Institute via AP) This image provided by Nathan ...

From the Center for Systems Biology (W.C.P., M.N., F.K.S.), Massachusetts General Hospital and Harvard Medical School, Boston. From the Center for Systems Biology (W ...