Lactic acid generates a low pH level in the tumor microenvironment that makes it difficult for immune cells to properly function. Lactic acid fermentation or production was also found to limit ...

As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells -; which have lost their cancer-fighting oomph -; consume this ...

Study uses spatial transcriptomics to map intratumoral heterogeneity and microenvironmental dynamics in triple-negative ...