Localization of cyclases and corresponding PDEs within intracellular domains, along with their varying expression across different cell types, adds multiorgan complexity to cGMP signaling. This ...

These variations are particularly evident in the intracellular domain of NKG2A, manifested as changes in mobility, tyrosine exposure, and interdomain communication. Additionally, we found that a large ...

Notably, intracellular checkpoint molecules within NK cells, such as FBP-1, EZH2, CIS, TIPE2, and HIF-1α, play a significant role in NK cell exhaustion by affecting their metabolism ...

Bacteria-containing phagosomes that were formed by the ASM-dependent rapid uptake pathway are delayed in their maturation and the bacteria do not escape these organelles efficiently, hence ...