Scientists discover how the Fas-p53 pathway sabotages energy metabolism, offering new hope for tackling obesity and improving ...

Investigators at the Helmholtz Institute have shown that inceptor, an inhibitor of the insulin signaling pathway, acted by binding insulin and targeting it for ... which were published online in ...

insulin resistance and type 2 diabetes, these chronic diseases are strongly influenced by pathways that lie at the interface of chronic inflammation and nutrient metabolism. Here I discuss recent ...

Leptin and Insulin Resistance Pathway Convergence ... interplay between leptin resistance, obesity, and metabolic syndrome, revealing pathways that offer potential targets for therapeutic ...

Objective, but not subjective, EDS was associated with insulin resistance and disordered glucose metabolism among patients with OSA.

Objective—Insulin stimulates brain glucose metabolism, but this effect of insulin is already maximal at fasting concentrations in healthy subjects. It is not known whether insulin is able to ...

In addition, there is evidence that in type 2 diabetes, the activation of these same pathways by elevations in glucose and free fatty acid (FFA) levels leads to both insulin resistance and ...

Insulin signaling pathways remained comparable between the ... Overnutrition causes insulin resistance and metabolic disorder ...

Three years ago, the inceptor protein was discovered and its role as an inhibitor of the insulin signaling pathway was described ... work is published in Nature Metabolism in the paper ...

When insulin metabolism goes awry, cells lose their ability to efficiently take in glucose, so blood sugar levels stay ...