This model is based on a critical observation we made: diabetes in animals and patients, and hyperglycemia in cells, all decrease the activity of the key glycolytic enzyme glyceraldehyde-3 ...
Recently, rasagiline has been shown to inhibit glyceraldehyde-3-phosphate dehydrogenase (GAPDH), an enzyme that catalyzes the sixth step of glycolysis and participates in the initiation of apoptosis.
Band intensities were quantified in densitometric units (du). All data were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Results: HDAC-2 proteins levels normalized to GAPDH were ...
Chronic exposure to hyperglycemia can lead to cellular dysfunction that may become irreversible over time, a process that is termed glucose toxicity. Our perspective about glucose toxicity as it ...
This month's cover highlights the article Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis by Tobias Ackermann, Saverio Tardito and colleagues. The ...
2 Microbiology and Tumour Biology Centre, Karolinska Institute, Stockholm, Sweden 3 Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden 4 Microbiology and Tumour ...