Objective—Glucagon-like peptide 1 (GLP-1) exerts beneficial antidiabetic actions via effects on pancreatic β- and α-cells. Previous studies have focused on the improvements in β-cell function ...

Glucagon is a peptide hormone secreted primarily from the alpha cells of the pancreatic islets of Langerhans. Minor amounts are also produced in the L cells of the intestine and certain neurons of ...

The term "nonalcoholic fatty liver disease" (NAFLD) has long been used to describe liver steatosis not related to excessive alcohol consumption ...

New research found that some anti-obesity medications such as Wegovy and Zepbound may prompt people to drink less. These ...

A panelist discusses how glucagon-like peptide-1 receptor (GLP-1) agonists' cardioprotective effects likely stem from multiple physiological mechanisms, including reduced inflammation, improved ...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently a pressing public health issue associated with ...

Semaglutide is a synthetic analog of the glucagon-like peptide-1 (GLP-1), an endogenously occurring hormone integral to the regulation of glucose metabolism. This peptide has garnered significant ...

Patients who have heart failure with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) and high body mass index ...

Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs ... (T2D, type 2 diabetes; CVD, cardiovascular disease; NO, nitric oxide; ER, endoplasmic reticulum). Another mechanism theory for ...

Scientists uncover how TRH neurons suppress hunger by inhibiting AgRP neurons, advancing our understanding of GLP-1-based ...

But weight loss alone does not explain the drugs’ benefits. Both Holst and Sattar pointed to a discontinued GLP-1 drug once ...