To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. This may be done by deleting portions of the gene's DNA sequence to make it nonfunctional ...

geneticists can generate knockout mice in which the mouse counterpart of a human gene of interest is deleted or disrupted. The term "knockout mouse" may at first conjure images of a mouse boxing ...

One such gene is Astrotactin 2 (ASTN2 ... Hanzel spent two years creating a knockout mouse that lacked ASTN2, and then studied the brains and activity of both infant and adult mice.

A research group has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin promote sleep. This study revealed that the balance ...

While previous attempts have been made, in-depth phenotypic changes resulting from mitochondrial gene knockout, i.e., the ...

Another type of transgenic mouse, called a PrP "knockout" mouse has its PrP gene disrupted or made inactive. PrP knockout mice do not make PrP. These mice do not become diseased and do not produce ...

Researchers have uncovered how loss of the MeCP2 protein triggers early molecular changes leading to Rett syndrome, a severe ...

A gene therapy based on an enhanced lipid nanoparticle (LNP) loaded with vascular endothelial growth factor (VEGF) mRNA could be developed for the treatment of preeclampsia, according to a study in ...

Animal imaging studies also confirmed the effects of the gene therapy were limited to cancer tissue and were undetectable in normal tissue.

to knockout and characterize all protein-coding genes in the mouse genome. Knocking out the activity of a gene provides valuable clues about what that gene normally does. However, creating and ...

While previous attempts have been made, in-depth phenotypic changes resulting from mitochondrial gene knockout ... within the cerebral cortex of these mice, accompanied by hippocampal atrophy ...