Here, we report the genotypes and phenotypes of heteroplasmic MT-ND5 gene-knockout mice. These mutant mice presented damaged mitochondrial cristae in the cerebral cortex, hippocampal atrophy, and ...

Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas ...

With Gene Editing, Mice With a Form of Inherited Deafness Can Hear Again July 12, 2024 — Researchers have used gene editing to restore hearing in adult mice with a type of inherited hearing loss.

Mitochondria possess their own DNA (mtDNA), which plays important roles in cellular respiration and energy consumption.

However, the molecular mechanisms involved in sleep regulation remain unclear. Professor Hiroki Ueda, Doctoral Student Yimeng ...

This study investigates the role of Aff3ir-ORF2, a novel nested gene variant, in disturbed flow-induced endothelial cell activation and atherosclerosis. We demonstrate that disturbed shear stress ...

Conditional alleles may be given priority when knockout alleles ... at the gene expression level. Finally, we note that introducing experimental envirotypes into mouse phenotyping protocols ...

Gene therapy that selectively delivers the SMN1 gene to the liver reduced alterations related to spinal muscular atrophy (SMA) in a mouse model, restoring muscle size and correcting pancreatic issues.

A research group has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin promote sleep. This study revealed that the balance ...

While previous attempts have been made, in-depth phenotypic changes resulting from mitochondrial gene knockout ... within the cerebral cortex of these mice, accompanied by hippocampal atrophy ...

Researchers have uncovered how loss of the MeCP2 protein triggers early molecular changes leading to Rett syndrome, a severe ...