Each data point will be collected in triplicate and replicated with primary fibroblasts obtained from ... Immunofluorescence assessed alpha-smooth muscle actin and collagen I deposition for ...

LUMC.nl Background: Matrix metalloproteinases (MMPs) have a pivotal role in the destruction of cartilage in rheumatoid arthritis (RA), which is mediated by the fibroblast-like synoviocytes (FLS ...

The evidence for the authors' claims is convincing, combining state-of-the-art conditional gene deletion in the mouse lens with histological and molecular approaches. This work should be of great ...

Fibroblasts are specialized cells in connective tissues that play an important role in wound healing and tissue repair. They produce and organize the so-called extracellular matrix, a network of ...

A study provides insights into the diversity of cancer-associated fibroblasts in white and black skin cancer and describes their different immunomodulatory roles in the tumor environment.

This is a useful report of a spatially-extended model to study the complex interactions between immune cells, fibroblasts, and cancer cells, providing insights into how fibroblast activation can ...

In atherosclerosis, the vascular smooth muscle cell (VSMC) contributes to vessel wall inflammation and lipoprotein retention, as well as to the formation of the fibrous cap that provides stability ...

Evaluation of Fibroblast Activation Protein Expression Using 68Ga-FAPI46 PET in Hypertension-Induced Tissue Changes Fibroblast Activation Protein-Directed Imaging Outperforms 18F-FDG PET/CT in ...

1 Department of Pharmacy, The Affiliated Yixing Hospital of Jiangsu University, Yixing, China 2 Department of pharmacy, Jiangsu Province Hospital, Nanjing, China Immunotherapy has become a global ...

Sections were encircled with a hydrophobic barrier ImmEdge pen (H-4000, Vector Laboratories) and stained with AXL (cat# AF854, R&D Systems), F4/80 (cat# 70076S, Cell Signaling Technology), or ...