A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the ...

A new method can improve treatment for patients with chronic myeloid leukemia by predicting which medication will be most ...

A study from the University of Michigan Health Rogel Cancer Center may have—at last—cracked the cold case of immunotherapy ...

These medications inhibit the activity of one or more of the Janus kinase enzymes (JAK1, JAK2, JAK3, and TYK2 ... There are side effects common to all JAK inhibitors, and each JAK inhibitor has its ...

These preliminary results seem to support a mechanism of competitive inhibition as has been shown in vitro, rather than an irreversible inhibition as has been shown in the rat in vivo. 4 Probably ...

Researchers reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected 'second jobs' within the nucleus, orchestrating critical ...

The term “protease inhibitor” refers to a class of medications ... They all have the same goal of blocking specific proteolytic enzymes (proteases) in the body, although each of these drugs ...

Ibuprofen counters problems caused by mutations in the MAN1B1 gene, fruit fly tests show. Early results in three children are ”fairly positive.” ...

Fully automated pipeline allows for 500.000 binding energy predictions per month to speed up in silico enzyme and inhibitor screening and discovery projects GELEEN, NETHERLANDS, October 31 ...

Here, by combining Rosetta in silico, in vitro, and in cellulo methods, we investigate the target specificity and inhibition mechanisms of POPs. We find here that POP1 is ineffective in directly ...