Researchers at the University of Chicago have successfully captured detailed images of adhesion G protein-coupled receptors, ...

Researchers at the University of Chicago have captured complete images of adhesion G protein-coupled receptors and an ...

In the inactive conformation, the a-subunit of the G protein binds to GDP and is bound to a beta-gamma complex (a). Upon receptor activation by its ligand, there is an exchange of GDP for GTP (b).

Glycans can be incredibly complex and branched in structure, contributing to the stability of the extracellular domain of ...

Almost 35% of drugs approved by the Food and Drug Administration work by targeting G protein-coupled receptors (GPCRs), ...

The common understanding of how to activate an aGPCR is that a ligand from outside the cell attaches to one of the extracellular domains and exerts force that separates the GAIN domain from its ...