The current study presents useful findings about the inhibition of a membrane pyrophosphatase by non-hydrolyzable phosphonate substrate analogs. The study proposes a model in which the two monomers in ...

Although angiotensin-converting enzyme inhibitors are frequently used as antihypertensive agents to lower blood pressure and slow progression of nephropathy in patients with type 2 diabetes ...

Influencing their activity can control their rates of reaction. Different chemicals can influence enzyme activity. Inhibitors can be used to stop an enzyme from binding to its substrate.

Angioedema is a well-recognized side effect of angiotensin-converting enzyme (ACE) inhibitor therapy. Angioedema can also be seen with angiotensin receptor blocker therapy but much less frequently ...

How does your body speed up these important reactions? The answer is enzymes. Enzymes in our bodies are catalysts that speed up reactions by helping to lower the activation energy needed to start a ...

This manuscript provides fundamental studies to help us better understand the effects of mutations in the presenilin-1 (PSEN1) gene on proteolytic processing of the amyloid precursor protein (APP).

What do you notice about where we work now? What do you wonder? By The Learning Network A new collection of graphs, maps and charts organized by topic and type from our “What’s Going On in ...

One class of ARTs, integrase inhibitors, has become a standard HIV ... it takes control of them by making integrase, a type of enzyme. The virus then spreads by reproducing itself and taking ...

Inflammation is limited when the enzyme signaling pathways are interrupted, which can help some autoimmune diseases. In this article, learn about the dosage, uses, and ongoing research underway for ...