And strategies for developing cuproptosis inducers and inhibitors involved in these targets have been continuously ... redox homeostasis and mitochondrial respiration through activating the target ...

In animal models, protection against cancer, and many chronic diseases, can be accomplished by induction of the Keap1/Nrf2 pathway, which controls the gene expression of numerous cytoprotective ...

Researchers reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected 'second jobs' within the nucleus, orchestrating critical ...

has described proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety coupled to a probable global transcription activator SNF2L2 (SMARCA2; BAF190B; SNF2-α) and/or ...