A new study in Nature identifies a long-sought cytoplasmic 'sensor' that is responsible, at least in part, for interferon responses induced by double-stranded DNA. How do cells detect non-self ...

Since SAM domains are found in cell surface receptors, cytoplasmic signaling proteins, and transcriptional activators and repressors, as well as chimeric human oncoproteins, these results have ...

Tension inference is also most robust on the local level, since this is where force balance, the underlying physical determinant of the link between mechanics and geometry, resides. In global tension ...

Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease which, if untreated, often leads to cirrhosis, liver failure and death. Major advances were made in its management based on ...

2008). In N. benthamiana functional N-glycan sialylation could be achieved in a transient approach by co-expressing five CDSs of the sialylation pathway-genes, together with a chimeric GalT4 ...

Parkinsonian diseases comprise a heterogeneous group of neurodegenerative disorders, which show significant clinical and pathological overlap. Accurate diagnosis still largely relies on clinical ...

This is a retrospective study of the history, roentgenology and autopsy pathology when appropriate of all infants with severe respiratory-distress syndrome who required twenty-four hours or more ...

N6-methyladenosine is one of the most common and reversible post-transcriptional modifications in eukaryotes, and it is involved in alternative splicing and RNA transcription, degradation, and ...

Cell competition in epithelial tissue eliminates transformed cells expressing activated oncoproteins to maintain epithelial homeostasis. Although the process is now understood to be of mechanochemical ...

Section of Digestive Diseases and Nutrition, University of Illinois at Chicago and Chicago Veterans Administration Medical Center (West Side Division), Chicago, IL, USA Correspondence to: Dr G Hecht, ...