Results: The pharmacokinetics of intravenous fentanyl reflected a 2-compartment model with a clearance of approximately 1.5 L/min. There was moderate (< 50%) between-subject variability (BSV ...

As found in the separate modeling of the intravenous and nasal data, the 2-compartment model with an estimated bioavailability and an absorption lag for the nasal route was the best fit of the data.

Population pharmacokinetics analysis was conducted using NONMEM software. Results Sparse pharmacokinetic samples (n=100) from 85 neonatal patients were available for analysis. A one-compartment model ...

The chosen pharmacokinetic model that was used to simulate the drug concentration time curves was an excellent fit to the observed plasma concentration data. The predicted concentrations of ...

Adaptive Control,Adaptive Control Algorithm,Anti-angiogenic Therapy,Cancer Therapy,Concentration In Compartment,Discrete-time,Drug Dose,Dynamical,Feedback Gain ...

and pharmacokinetic parameters calculated employing one- and two-compartment models as well as non-compartmental analysis. The pharmacokinetics of mifepristone ...

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Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China University of Chinese Academy of ...

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Furthermore, this call invites studies that elucidate the pharmacokinetic profiles of various therapeutic agents targeting redox signaling pathways in the context of inflammation-associated diseases.

Amount Of Material,Antibody Clearance,Blood Flow,Clearance Rate,Disease Status,Endogenous IgG,Endosomes,Fluid-phase Endocytosis,Fraction Of Space,Human Disease States,Interstitium,Kidney ...