The median relapse time after the cessation of treatment was 5 weeks ... 2 months of continual application of 0.1% tacrolimus ointment twice per day. [87] Two patients with necrobiosis lipoidica ...

The patients experienced clearing or significant improvement after 1 to 2 months of treatment with 12.5 to 20.0 mg of methotrexate weekly. [81] Other oral agents that may be used for the treatment ...

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