Given the newfound role of NRP1 in nerve growth factor pain signaling, the researchers envision several ways that this knowledge can be used to redeploy existing therapies to treat pain and create ...

Mutations in genes encoding receptors for these growth factors (EGFR and FGFR) are commonly observed in cancers. 2 The EGF signaling pathway regulates cell growth, proliferation, differentiation ...

2020). In the complex signaling transduction process, Protein kinase C (PKC) is a key effector molecule within the G protein-coupled receptor system. Figure 2. Oxidative stress pathways in CI-AKI. CM ...

Innate immune signaling pathways of TLRs, IL1-Rs, and TNFRs ... as well as reduced transcription of chemokines CCL2 (MCP1), CCL3 (MIP1α), and chemokine receptor CX3CR1. Consequently, the infiltration ...

The study highlights adhesion G-protein-coupled receptor A3 (ADGRA3) as a potential target for activating adaptive ... and hesperetin in inducing the development of beige adipocytes through the ...

Acquired resistance to PD-L1 inhibition can rewire the interferon-regulated secretory machinery in tumor cells, altering the ...

Teos Therapeutics (ITOS) announced the presentation of clinical, translational, and preclinical data from its adenosine A2A receptor ...

Cys-loop receptors are ligand-gated ion channels with two domains connected by a short linker. The top domain is located extracellularly, while the bottom domain sits in the cell membrane.When an ...