By examining nine mouse tissues, researchers pinpointed specific regions — known as senescence-sensitive spots (SSSs) — characterized by cellular disarray and a buildup of immunoglobulins. This ...
When a telomere attains a critical short length, cells recognize it, and replication is attenuated, which results in cell senescence. Previous studies have indicated that magnesium maintains telomeric ...
In this study, our results uncover the function and mechanism of CHMP5 in the regulation of cell senescence and bone formation in osteogenic cells. Deletion of Chmp5 causes endolysosomal dysfunction ...