Enhanced FIB-SEM images of untreated cells and cells treated with Torin, which causes nutrient stress. The ER exit sites (magenta), ER (blue), and all lysosome-related organelles (cyan ...

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed—for instance ...

Scenarios in which ER stress contributes to disease are outlined and prospects for drug discovery are discussed. Among the cell death mechanisms addressed are: pro-apoptotic signals resulting from ...

including the stress that arises from the accumulation of unfolded proteins within a cell's endoplasmic reticulum (ER). To counterbalance this type of ER stress, higher eukaryotic cells possess a ...

Pancreatic cells, like human cells, have a limit to how much stress they can handle before they start to break down. Through ...