Scenarios in which ER stress contributes to disease are outlined and prospects for drug discovery are discussed. Among the cell death mechanisms addressed are: pro-apoptotic signals resulting from ...

The surfaces that cells come into contact with can influence how the cells grow, function, and communicate—shaping metabolism ...

Researchers investigating ways to reduce exhaustion in cancer-fighting T-cells found that the Golgi apparatus can be used as a simple marker -- more Golgi means a more robust cell.

Pancreatic cells, like human cells, have a limit to how much stress they can handle before they start to break down. Through ...

including the stress that arises from the accumulation of unfolded proteins within a cell's endoplasmic reticulum (ER). To counterbalance this type of ER stress, higher eukaryotic cells possess a ...

It is upregulated in cells that actively secrete proteins, and in various situations where protein aggregates accumulate in the endoplasmic reticulum (ER), causing ER stress. The exact mechanism of ...

Enhanced FIB-SEM images of untreated cells and cells treated with Torin, which causes nutrient stress. The ER exit sites (magenta), ER (blue), and all lysosome-related organelles (cyan ...

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed—for instance ...

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed -- for instance ...