Scenarios in which ER stress contributes to disease are outlined and prospects for drug discovery are discussed. Among the cell death mechanisms addressed are: pro-apoptotic signals resulting from ...

including the stress that arises from the accumulation of unfolded proteins within a cell's endoplasmic reticulum (ER). To counterbalance this type of ER stress, higher eukaryotic cells possess a ...

Enhanced FIB-SEM images of untreated cells and cells treated with Torin, which causes nutrient stress. The ER exit sites (magenta), ER (blue), and all lysosome-related organelles (cyan ...

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed—for instance ...

Pancreatic cells, like human cells, have a limit to how much stress they can handle before they start to break down. Through ...