The level of CYP3A4 expression may determine which patients best respond to certain drugs, and which patients experience side effects or even toxicity when the same dosage is administered.

does not interact with CYP3A4 substrates. Pitavastatin is well tolerated. As such, pitavastatin shows distinctive pharmacokinetic and clinical profiles that should help a greater proportion of ...

May potentiate cyclosporine. May antagonize anticoagulants (monitor), isoniazid, other CYP3A4 substrates (eg, indinavir, erythromycin). Increased risk of arrhythmias with digitalis. May need to ...

Omeprazole is metabolized directly in part by CYP3A4 to omeprazole sulfone ... Based on the rate of metabolism of CYP2C19 substrates, three groups can be distinguished depending on their genotype ...

May potentiate cyclosporine (seizure risk). May antagonize anticoagulants (monitor), isoniazid, other CYP3A4 substrates (eg, indinavir, erythromycin). Increased risk of arrhythmias with digitalis.