I believe Cyclin-Dependent Kinase 9 (CDK9) inhibitors are one modality that will bring us a step closer to that future. By targeting the fundamental processes that enable cancer cell survival ...

The company has discontinued the Phase I/II trial of its only clinical candidate due to a potential “unfavourable ...

We also propose key intracellular pathways that may be involved in regulating HIV-1 replication via protein kinase complexes, CDK9/cyclin T1 and CDK2/cyclin E, protein phosphatase-1 and other host ...

Effect of Hypoxia on HIV-1 Hypoxia inhibits HIV-1 by decreasing CDK9/cyclin T1 activity. The effect of hypoxia could be due to deregulation of protein phosphatase-1 and/or increased expression of p27.

(C) Bifunctional ATTECs targeting oncoprotein NAMPT. (D) Bifunctional ATTECs targeting oncoprotein CDK9/cyclin T1. (E) Bifunctional ATTECs targeting lipid droplets.