BRAF, a member of a serine/threonine kinase protein family, serves as an immediate downstream effector of RAS in the MAPK signaling cascade, a signal transduction pathway that transmits mitogenic ...
爱思益普可提供MAP2K4靶点筛选服务。MAP2K4采用ADP-Glo方法进行筛选。ADP-Glo是一种通过量化激酶反应期间产生的 ADP 的量来测量激酶活性的方法，也是一种通用、均相、高通量筛选的方法。该测定分两步进行：首先，在激酶反应后，加入 ...
One of the standard treatment options for melanoma over the last 10 years has been to simultaneously target both BRAF mutations and MEK. These two genes are part of the MAPK signaling pathway ...
It is caused by heterozygous mutations in the RAS/MAPK pathway genes BRAF, MAP2K1, MAP2K2, and KRAS. The cardiofaciocutaneous syndrome (CFCS) is inherited as an autosomal dominant trait.
BRAF and CRAF potentially creating a more complete and durable anti-tumor response through maximal RAS/MAPK pathway inhibition. In contrast to currently available MEK-only inhibitors, avutometinib ...
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