In α-LA, the helical domain is not contiguous, with the central segment of the polypeptide ... Both the N- and C-terminal helices are highly amphipathic, and the burial of hydrophobic residues ...

Sequence alignment of αF-helix segment of PKA with other kinases. All share a very hydrophobic helix ... High-affinity binding of PKI is mediated by the hydrophobic surface of an amphipathic helix and ...

Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States ...