Exploration of adenosine mechanism revealed adenosine receptors as a potentially useful target of therapy in RA.

Exploration of adenosine mechanism revealed adenosine receptors as a potentially useful target of therapy in RA.

Dopamine’s effects in the brain are mediated by postsynaptic D1 and D2 receptors. Adenosine A1 and A2A receptors are uniquely positioned to counteract the excessive stimulation of dopamine receptors ...

The authors conclude that nonsynaptic release of ATP and subsequent activation of adenosine A 1 receptors contributes to suppression of thalamic activity and tremor, alone and during DBS ...

We showcase the extraction and purification of the Adenosine A2a G-protein coupled receptor (GPCR) and the subsequent use of a Spectral Shift binding assay for fragment screening. Fig 2.