Adenosine and various adenosine receptor ligands acting at adenosine A 1 and A 2A receptors have been explored in several experimental models of drug addiction. The therapeutic effects of the ...
Oxford, UK-based Exscientia has been working with German biotech Evotec on the adenosine A2a receptor antagonist, which is being tested as a treatment for adult patients with advanced solid tumours.
G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...
Recent advances in neurobiology and PET have helped redefine Alzheimer's disease (AD) as a dynamic pathophysiological process, clinically characterized by preclinical, mild cognitive impairment ...
This valuable study proposes a novel rapid-entry mechanism of S. aureus that involves the rapid release of calcium from lysosomes. The strength of the paper lies in a very interesting hypothesis; what ...
1 Laboratory for Molecular Liver Cell Biology, Free University Brussels (VUB), Brussels, Belgium 2 Department of Medical Cell Biology and Centre for Liver Research, University of Newcastle-upon-Tyne, ...
Here, the authors show that spinal microglia regulate plasticity in motor neurons that drive breathing through reciprocal fractalkine and adenosine signaling. Bruton’s tyrosine kinase (BTK ...