We have been exploring the potential of the neuromodulator, adenosine, to reduce excessive dopamine signaling that contributes to the development and persistence of psychostimulant abuse. Dopamine’s ...

Exploration of adenosine mechanism revealed adenosine receptors as a potentially useful target of therapy in RA.

The authors conclude that nonsynaptic release of ATP and subsequent activation of adenosine A 1 receptors contributes to suppression of thalamic activity and tremor, alone and during DBS ...

Exploration of adenosine mechanism revealed adenosine receptors as a potentially useful target of therapy in RA.

We showcase the extraction and purification of the Adenosine A2a G-protein coupled receptor (GPCR) and the subsequent use of a Spectral Shift binding assay for fragment screening. Fig 2.