Within the atherosclerotic lesion, macrophage-derived foam cells (MDFc) play a crucial role in disease pathogenesis. Research question: This study addressed the role of cFAS in macrophage-derived foam ...

Conclusion: We demonstrate that TET2 deficiency stimulates foam cell formation through increased LDL and oxLDL uptake, possibly due to aberrant activation of LDLR and VLDLR. These data suggest that ...