Hepatocellular carcinoma (HCC) is a significant global health issue, ranking as the sixth most prevalent malignancy and the ...

Surrounding these epithelial cells is a microenvironment of supporting ... effects on lymphocytes and indirectly by tuning tumor-associated macrophages function.

封底插图： 在肿瘤内部恶劣的环境中，膀胱癌细胞（喻为 红鱼 ）通过释放趋化因子CCL2来吸引巨噬细胞（喻为黑鱼）。作为响应，巨噬细胞释放细胞因子IL-6，辅助肿瘤细胞的增殖和干性维持，形成了一种促进肿瘤恶性生长的共生关系。这种互作关联揭示了肿瘤微环境中细胞间复杂的相互作用，也凸显了肿瘤进展中的关键调控机制。

Prostate cancer vaccines, including dendritic and peptide types, offer hope for improved treatments, but face hurdles in ...

Cancer cells impair monocyte-mediated T-cell activation by disrupting inflammatory pathways in the tumor microenvironment.

In a study published in Cell Reports Physical Science on Nov. 25, a research team reported the development of an innovative ...

Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...

About Pilatus Biosciences Inc.: Pilatus Biosciences is pioneering in discovering and developing first-in-class antibodies and ...

In recent years, the tumor microenvironment (TME ... is densely populated by protumoral glioma-associated microglia and macrophages (GAMs),” the researchers found. “Myeloid immune checkpoint ...