Cancer remains one of the most complex diseases, with its diverse molecular profiles and cellular compositions posing ...

Notch signaling and epithelial-to-mesenchymal transition (EMT). Transformed, recruited and differentially activated cells surrounding the tumor form the tumor microenvironment. These cells inhibit ...

The tissue adjacent to a tumor behaves differently than areas farther away: The tumor’s cancerous cells influence their surroundings, blocking the body’s immune defenses and creating a sort of haven ...

Researchers in the group of Associate Professor Ninib Baryawno, Department of Women's and Children's Health, KI, have ...

"Build your enemy a golden bridge to retreat across" is a piece of advice offered by Sun Tzu in his ancient military treatise ...

Researchers have designed process that uses ultrasound to modify the behavior of cancer-fighting T cells by increasing their cell permeability. They targeted freshly isolated human immune cells with ...

Engineered extracellular vesicles show promise in targeting cancer cells and immunosuppressive stromal cells, offering a ...

Epithelial cancer cells subvert the EMT program. By activating a usually ... which requires a disseminated cancer cell to adapt to the foreign microenvironment of the tissue in which it happens ...

Studies to determine whether epigenetic reprogramming of EMT and/or the tumor microenvironment will improve response to standard-of-care chemotherapy and immunotherapy. View a listing of lab members ...

We are focusing on the regulation of growth and phenotype in embryonic and metastatic stem cells, mesenchymal cells and immune cells in the tumor microenvironment ... Aberrant TGF-β signaling and EMT ...

Despite recent therapeutic breakthroughs, cancer patients continue to face high recurrence and mortality rates due to treatment resistance. Cancer stem cells (CSCs), a subpopulation with self-renewal ...