Notch signaling and epithelial-to-mesenchymal transition (EMT). Transformed, recruited and differentially activated cells surrounding the tumor form the tumor microenvironment. These cells inhibit ...

Tumor cells undergoing epithelial–mesenchymal transition (EMT) can profoundly modulate their microenvironment via enhanced secretion of multiple soluble factors, including IL-8, IL-6 ...

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Cancer development and ...

Study uses spatial transcriptomics to map intratumoral heterogeneity and microenvironmental dynamics in triple-negative ...

We are focusing on the regulation of growth and phenotype in embryonic and metastatic stem cells, mesenchymal cells and immune cells in the tumor microenvironment. The work incorporates signal ...

The tumor cells are too varied, and the microenvironment is too tumor-friendly. Researchers have now developed an immunotherapy that not only attacks the tumor -- it also turns its ...

Furthermore, researchers have observed that the two cell populations have very different locations within the tumor. The ...

Furthermore, researchers have observed that the two cell populations have very different locations within the tumor. The ...