We selected a set of targets to interrogate the immune tumor microenvironment 7: T cells (CD4, CD8), B-cells (B220), myeloid cells including dendritic cells (CD11b, MHC II, CD11c) and functional ...

老规矩，奇点糕开头先问大家一个问题：在激活CD8+T细胞抗肿瘤免疫应答时，有哪些细胞会起到重要作用呢？回答树突状细胞（DCs）是肯定没问题的，它们的抗原呈递功能确实广为人知，但各位要记住了，从今天开始DCs可就不是问题唯一的“正解”了。因为在今天的《 ...

they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Newly reported research by scientists at the University of Pittsburgh and UPMC Hillman Cancer Center ...

Prostate cancer and other cancers characterized by “cold” tumors could become more responsive to checkpoint blockade if UBA1 is inhibited.

The interactions between cells in the tumor microenvironment (TME) are critical to tumor initiation, progression, metastasis and therapeutic responses. As a key target in cancer research and ...

A study from the University of Michigan Health Rogel Cancer Center may have—at last—cracked the cold case of immunotherapy ...

引言癌症是当今世界上最具挑战性的健康问题之一，尤其是肺癌，作为致死率最高的癌症类型，每年夺走数百万人的生命。随着研究人员对癌症的深入研究，人们逐渐认识到，癌症不仅仅是恶性细胞的过度增殖，更是一种与“宿主”复杂相互作用的生态系统。肿瘤微环境（Tumor ...

They also tested healthy CD8+ T cells treated with the ascites ... The study found that the tumor microenvironment in ovarian cancer inhibits the uptake of fatty acids or lipids by CD 8+ T cells ...

We utilize various research methods to understand how dendritic cells regulate gene expression, use critical molecules to instruct the immune system, prime other immune cells like cytotoxic T cells, ...

University of Michigan researchers identified UBA1 as a key player in immunotherapy resistance. Inhibiting UBA1 boosts T-cell ...

Researchers found that methylmalonic acid treatment significantly reduced the activity of CD8+ T cells ... of methylmalonic acid in skewing the tumor microenvironment, affecting not only T ...