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肝癌新发现:乳酸化修饰如何推动癌症进展
2025年1月3日,南京医科大学附属泰州人民医院的研究小组在国际著名期刊《Cell Death & Differentiation》上发表了一项具有突破性的研究,揭示了非组蛋白ABCF1的乳酸化修饰(ABCF1-K430la)如何通过HIF1信号通路加速肝细胞癌(HCC)的恶性进展,并找到了新的小分子药物Tubuloside A(TubA),显示出潜在的抗癌效果。 研究背景及意义 乳酸不仅是肿瘤细 ...
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