New research combines two powerful imaging techniques to study the complete structure of a common aGPCR, including how its long and complex extracellular region interacts with the transmembrane ...

This opens up new opportunities for drugging adhesion GPCRs, because now we are showing that the extracellular region is communicating with the transmembrane region." The extracellular region of ...

Clearly, the conformational changes that occur in the transmembrane region are somehow transmitted to the cytoplasmic domain, which then alters its shape to one suitable for interaction with G ...

Transmembrane proteins involve various physiological functions, including protein ligation, recognition, transport, anchoring, and transduction. Several diseases are connected with abnormalities ...

Gait instability and somnolence are the main hindbrain-related adverse effects associated with the inhibition of AMPA receptors (AMPARs). Transmembrane AMPAR regulatory proteins (TARPs) modulate AMPAR ...

"This opens up new opportunities for drugging adhesion GPCRs, because now we are showing that the extracellular region is communicating with the transmembrane region," said Demet Araç, Ph.D ...